There have been major improvements regarding therapeutic treatments for various human medical diseases. This includes gene therapy, several anti cancer treatments and now clodronate liposome. Indeed, the latter have showed promising results that might help on the treatment of various autoimmune diseases, prevention of transplantation rejection and most importantly, cancer.
Apart from cardiovascular and metabolic diseases, autoimmune diseases and cancer are among the common medical condition of people through out the world. What’s worse is that both diseases remains to be incurable as all present therapies focuses on how to slow down the progression or worsening of the disease.
It activates the process of T and B lymphocytes, meaning they are the ones that can activate the immune system to work. Such phenomenon though is a good thing as it defends human from getting sick such as flu or any another viral diseases. But, this could also be a bad thing especially to those that have autoimmune diseases or to people that just had a transplant operation.
In normal circumstances, this process makes the body cope up with simple diseases such as colds or cough, thus the term healthy immune system. However, a damage to the immune system could make it passive or overly active. An overly active immune system will result to autoimmune diseases, wherein your own immune cells are attacking your own cells causing several medical disorders.
Clodronate or also known as clodronic acid or clodronate disodium is a bisphosphonate that depletes macrophage hence reducing phagocytosis and suppresses the immune system. Liposomes on the other hand are artificially made lipid vesicles that are mostly used to encapsulate or carry strong hydrophilic substance in aqueous solution, for example clodronate.
During normal circumstances, such process is not harmful at all. Instead, it actually protects the body from infestation. But as mentioned, certain damages to the immune system could lead to serious autoimmune medical conditions. Transplant rejection is one of the effects of immune response. This time as the newly harvested organ is placed on the transplant patient, certain cells may trigger the immune system to attack the organ cells massively thus resulting to rejection.
To be able to manage such conditions, medical experts have stumbled upon clodronate, accidentally. Such experimental medicine is a bisphosphonate that is said to effectively deplete macrophage. Though the artificial lipid and drug vehicle liposome, clodronate is transported into the body. As soon as the macrophage detect such active drug as “foreign” this will automatically engulf it through phagocytosis.
More so as it reduces phagocytic cells, it is also believed to inhibit tumor growth. In some cancer research, this component has shown a significant depletion of Kupffer cells, a significant cancer cell especially to liver cancer resulting to increased plasma absorption and antitumor effect over some chemotherapeutic drugs.